Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 55519..56144 Replicon plasmid pEA11_1
Accession NZ_CP117669
Organism Escherichia albertii strain BIA_11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS054_RS23905 Protein ID WP_273815637.1
Coordinates 55519..55917 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8H9EG71
Locus tag PS054_RS23910 Protein ID WP_000450526.1
Coordinates 55917..56144 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS054_RS23865 (50789) 50789..52216 + 1428 WP_273815723.1 F-type conjugal transfer pilus assembly protein TraB -
PS054_RS23870 (52206) 52206..52796 + 591 WP_273815725.1 conjugal transfer pilus-stabilizing protein TraP -
PS054_RS23875 (52783) 52783..53103 + 321 WP_273815727.1 conjugal transfer protein TrbD -
PS054_RS23880 (53096) 53096..53347 + 252 WP_273815728.1 conjugal transfer protein TrbG -
PS054_RS23885 (53344) 53344..53859 + 516 WP_273815730.1 type IV conjugative transfer system lipoprotein TraV -
PS054_RS23890 (53994) 53994..54215 + 222 WP_213852945.1 conjugal transfer protein TraR -
PS054_RS23895 (54543) 54543..54590 + 48 Protein_62 hypothetical protein -
PS054_RS23900 (54639) 54639..55577 + 939 Protein_63 type IV secretion system DNA-binding domain-containing protein -
PS054_RS23905 (55519) 55519..55917 - 399 WP_273815637.1 type II toxin-antitoxin system VapC family toxin Toxin
PS054_RS23910 (55917) 55917..56144 - 228 WP_000450526.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - vat 1..110945 110945


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14885.20 Da        Isoelectric Point: 8.5264

>T271978 WP_273815637.1 NZ_CP117669:c55917-55519 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPVSVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.53 Da        Isoelectric Point: 4.5358

>AT271978 WP_000450526.1 NZ_CP117669:c56144-55917 [Escherichia albertii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References