Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4225873..4226491 Replicon chromosome
Accession NZ_CP117668
Organism Escherichia albertii strain BIA_11

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS054_RS20760 Protein ID WP_001280991.1
Coordinates 4225873..4226091 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS054_RS20765 Protein ID WP_000344798.1
Coordinates 4226117..4226491 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS054_RS20725 (4221162) 4221162..4221734 + 573 WP_000779847.1 YbaY family lipoprotein -
PS054_RS20730 (4221764) 4221764..4222075 - 312 WP_000409915.1 MGMT family protein -
PS054_RS20740 (4222456) 4222456..4222809 + 354 WP_000878151.1 DUF1428 family protein -
PS054_RS20745 (4222847) 4222847..4224397 - 1551 WP_001260378.1 EAL domain-containing protein -
PS054_RS20750 (4224561) 4224561..4225031 - 471 WP_000136188.1 YlaC family protein -
PS054_RS20755 (4225139) 4225139..4225696 - 558 WP_059221620.1 maltose O-acetyltransferase -
PS054_RS20760 (4225873) 4225873..4226091 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS054_RS20765 (4226117) 4226117..4226491 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS054_RS20770 (4227046) 4227046..4230195 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS054_RS20775 (4230218) 4230218..4231411 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271973 WP_001280991.1 NZ_CP117668:c4226091-4225873 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271973 WP_000344798.1 NZ_CP117668:c4226491-4226117 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References