Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2750212..2751012 Replicon chromosome
Accession NZ_CP117668
Organism Escherichia albertii strain BIA_11

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag PS054_RS13840 Protein ID WP_095574314.1
Coordinates 2750212..2750739 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS054_RS13845 Protein ID WP_001277106.1
Coordinates 2750746..2751012 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS054_RS13815 (2745288) 2745288..2746055 - 768 WP_000083515.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PS054_RS13820 (2746052) 2746052..2747329 - 1278 WP_273813827.1 branched chain amino acid ABC transporter permease LivM -
PS054_RS13825 (2747326) 2747326..2748252 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS054_RS13830 (2748300) 2748300..2749409 - 1110 WP_273813829.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS054_RS13835 (2749832) 2749832..2750215 + 384 WP_095574313.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS054_RS13840 (2750212) 2750212..2750739 - 528 WP_095574314.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS054_RS13845 (2750746) 2750746..2751012 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS054_RS13850 (2751162) 2751162..2752265 - 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS054_RS13855 (2752537) 2752537..2753391 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PS054_RS13860 (2753636) 2753636..2754694 - 1059 WP_113650495.1 permease-like cell division protein FtsX -
PS054_RS13865 (2754687) 2754687..2755355 - 669 WP_000617720.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19464.36 Da        Isoelectric Point: 6.6263

>T271963 WP_095574314.1 NZ_CP117668:c2750739-2750212 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRACILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVCSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271963 WP_001277106.1 NZ_CP117668:c2751012-2750746 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References