Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2162279..2162930 Replicon chromosome
Accession NZ_CP117668
Organism Escherichia albertii strain BIA_11

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS054_RS10935 Protein ID WP_000244763.1
Coordinates 2162279..2162683 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS054_RS10940 Protein ID WP_000354046.1
Coordinates 2162664..2162930 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS054_RS10915 (2158237) 2158237..2159970 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
PS054_RS10920 (2159976) 2159976..2160686 - 711 WP_273815377.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS054_RS10925 (2160711) 2160711..2161607 - 897 WP_273815378.1 site-specific tyrosine recombinase XerD -
PS054_RS10930 (2161719) 2161719..2162240 + 522 WP_059221135.1 flavodoxin FldB -
PS054_RS10935 (2162279) 2162279..2162683 - 405 WP_000244763.1 protein YgfX Toxin
PS054_RS10940 (2162664) 2162664..2162930 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS054_RS10945 (2162920) 2162920..2163150 - 231 WP_000181267.1 hypothetical protein -
PS054_RS10950 (2163182) 2163182..2164162 + 981 WP_059221136.1 tRNA-modifying protein YgfZ -
PS054_RS10955 (2164364) 2164364..2165023 - 660 WP_000250281.1 hemolysin III family protein -
PS054_RS10960 (2165191) 2165191..2165502 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS054_RS10965 (2165547) 2165547..2166980 + 1434 WP_164508673.1 6-phospho-beta-glucosidase BglA -
PS054_RS10970 (2167027) 2167027..2167920 - 894 WP_059221140.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271962 WP_000244763.1 NZ_CP117668:c2162683-2162279 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271962 WP_000354046.1 NZ_CP117668:c2162930-2162664 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References