Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 727094..727698 Replicon chromosome
Accession NZ_CP117668
Organism Escherichia albertii strain BIA_11

Toxin (Protein)


Gene name doc Uniprot ID A0A8H9B4D1
Locus tag PS054_RS03805 Protein ID WP_059222236.1
Coordinates 727094..727480 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS054_RS03810 Protein ID WP_001195490.1
Coordinates 727477..727698 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS054_RS03795 (722378) 722378..725878 + 3501 WP_273814871.1 ESPR-type extended signal peptide-containing protein -
PS054_RS03800 (725992) 725992..727092 + 1101 WP_273814873.1 autotransporter outer membrane beta-barrel domain-containing protein -
PS054_RS03805 (727094) 727094..727480 - 387 WP_059222236.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS054_RS03810 (727477) 727477..727698 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS054_RS03815 (728116) 728116..728874 + 759 WP_025239009.1 trans-aconitate 2-methyltransferase -
PS054_RS03820 (728878) 728878..729792 - 915 WP_024164792.1 bestrophin family protein -
PS054_RS03825 (729985) 729985..731436 - 1452 WP_059220135.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14475.47 Da        Isoelectric Point: 8.0833

>T271954 WP_059222236.1 NZ_CP117668:c727480-727094 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLADPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271954 WP_001195490.1 NZ_CP117668:c727698-727477 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References