Detailed information of TA system
Overview
TA module
| Type | III | Classification (family/domain) | toxIN/ToxN(toxin) |
| Location | 927..1695 | Replicon | plasmid pEA13_5 |
| Accession | NZ_CP117664 | ||
| Organism | Escherichia albertii strain BIA_13 | ||
Toxin (Protein)
| Gene name | toxN | Uniprot ID | - |
| Locus tag | PS034_RS25290 | Protein ID | WP_000675353.1 |
| Coordinates | 927..1442 (-) | Length | 172 a.a. |
Antitoxin (RNA)
| Gene name | toxI | ||
| Locus tag | - | ||
| Coordinates | 1443..1695 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PS034_RS25285 (105) | 105..815 | + | 711 | WP_024177388.1 | hypothetical protein | - |
| PS034_RS25290 (927) | 927..1442 | - | 516 | WP_000675353.1 | type III toxin-antitoxin system ToxN/AbiQ family toxin | Toxin |
| - (1493) | 1493..1550 | - | 58 | NuclAT_8 | - | - |
| - (1493) | 1493..1550 | - | 58 | NuclAT_8 | - | - |
| - (1493) | 1493..1550 | - | 58 | NuclAT_8 | - | - |
| - (1493) | 1493..1550 | - | 58 | NuclAT_8 | - | - |
| - (1493) | 1493..1586 | - | 94 | NuclAT_6 | - | - |
| - (1493) | 1493..1586 | - | 94 | NuclAT_6 | - | - |
| - (1493) | 1493..1586 | - | 94 | NuclAT_6 | - | - |
| - (1493) | 1493..1586 | - | 94 | NuclAT_6 | - | - |
| - (1493) | 1493..1622 | - | 130 | NuclAT_4 | - | - |
| - (1493) | 1493..1622 | - | 130 | NuclAT_4 | - | - |
| - (1493) | 1493..1622 | - | 130 | NuclAT_4 | - | - |
| - (1493) | 1493..1622 | - | 130 | NuclAT_4 | - | - |
| - (1493) | 1493..1658 | - | 166 | NuclAT_2 | - | - |
| - (1493) | 1493..1658 | - | 166 | NuclAT_2 | - | - |
| - (1493) | 1493..1658 | - | 166 | NuclAT_2 | - | - |
| - (1493) | 1493..1658 | - | 166 | NuclAT_2 | - | - |
| PS034_RS25295 (1496) | 1496..1687 | - | 192 | WP_196315241.1 | hypothetical protein | - |
| - (1529) | 1529..1694 | - | 166 | NuclAT_1 | - | - |
| - (1529) | 1529..1694 | - | 166 | NuclAT_1 | - | - |
| - (1529) | 1529..1694 | - | 166 | NuclAT_1 | - | - |
| - (1529) | 1529..1694 | - | 166 | NuclAT_1 | - | - |
| - (1443) | 1443..1695 | - | 253 | NuclAT_0 | - | Antitoxin |
| - (1443) | 1443..1695 | - | 253 | NuclAT_0 | - | Antitoxin |
| - (1443) | 1443..1695 | - | 253 | NuclAT_0 | - | Antitoxin |
| - (1443) | 1443..1695 | - | 253 | NuclAT_0 | - | Antitoxin |
| - (1565) | 1565..1698 | - | 134 | NuclAT_3 | - | - |
| - (1565) | 1565..1698 | - | 134 | NuclAT_3 | - | - |
| - (1565) | 1565..1698 | - | 134 | NuclAT_3 | - | - |
| - (1565) | 1565..1698 | - | 134 | NuclAT_3 | - | - |
| - (1601) | 1601..1698 | - | 98 | NuclAT_5 | - | - |
| - (1601) | 1601..1698 | - | 98 | NuclAT_5 | - | - |
| - (1601) | 1601..1698 | - | 98 | NuclAT_5 | - | - |
| - (1601) | 1601..1698 | - | 98 | NuclAT_5 | - | - |
| - (1637) | 1637..1698 | - | 62 | NuclAT_7 | - | - |
| - (1637) | 1637..1698 | - | 62 | NuclAT_7 | - | - |
| - (1637) | 1637..1698 | - | 62 | NuclAT_7 | - | - |
| - (1637) | 1637..1698 | - | 62 | NuclAT_7 | - | - |
| PS034_RS25300 (2762) | 2762..2953 | - | 192 | WP_000165987.1 | Rop family plasmid primer RNA-binding protein | - |
| PS034_RS25305 (3018) | 3018..3341 | + | 324 | WP_001508824.1 | MobC family plasmid mobilization relaxosome protein | - |
| PS034_RS25310 (3550) | 3550..3981 | + | 432 | Protein_5 | relaxase/mobilization nuclease domain-containing protein | - |
| PS034_RS25315 (4019) | 4019..4537 | + | 519 | WP_043991090.1 | MbeB family mobilization protein | - |
| PS034_RS25320 (4544) | 4544..4777 | + | 234 | WP_029401705.1 | MbeD family mobilization/exclusion protein | - |
| PS034_RS25325 (5090) | 5090..5371 | - | 282 | WP_024177387.1 | hypothetical protein | - |
| PS034_RS25330 (5381) | 5381..5638 | - | 258 | WP_001508827.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..6078 | 6078 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19763.71 Da Isoelectric Point: 5.6847
>T271943 WP_000675353.1 NZ_CP117664:c1442-927 [Escherichia albertii]
MKFYTISSSYIKYLKDFDDKVPNSEDPTYNNPKAFIGIVLEIEGHKYLAPLTSPKAWHANVKESSPAFFKLHENGVPDNQ
LGLINLKFMIPIIEAEVSLLDLDSMPDTPYKRMLYKQLQFIRVNEDKISEKSKLLRNLALQGRMQGTCDFAVLEEKYQHF
GKKPEDMEIDD
MKFYTISSSYIKYLKDFDDKVPNSEDPTYNNPKAFIGIVLEIEGHKYLAPLTSPKAWHANVKESSPAFFKLHENGVPDNQ
LGLINLKFMIPIIEAEVSLLDLDSMPDTPYKRMLYKQLQFIRVNEDKISEKSKLLRNLALQGRMQGTCDFAVLEEKYQHF
GKKPEDMEIDD
Download Length: 516 bp
Antitoxin
Download Length: 253 bp
>AT271943 NZ_CP117664:c1695-1443 [Escherichia albertii]
AAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGAT
TTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACC
TTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCTTAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTT
TTTACGAGAAAAA
AAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGAT
TTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACC
TTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCTTAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTT
TTTACGAGAAAAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
