Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1996..2543 Replicon plasmid pEA13_1
Accession NZ_CP117660
Organism Escherichia albertii strain BIA_13

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag PS034_RS23480 Protein ID WP_001384452.1
Coordinates 2265..2543 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A828ANF7
Locus tag PS034_RS23475 Protein ID WP_059272212.1
Coordinates 1996..2265 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS034_RS23470 (46) 46..1077 + 1032 WP_273784125.1 plasmid replication initiator RepA -
PS034_RS23475 (1996) 1996..2265 + 270 WP_059272212.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PS034_RS23480 (2265) 2265..2543 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
PS034_RS23485 (2979) 2979..3215 + 237 WP_032257624.1 colicin V immunity protein -
PS034_RS23490 (3193) 3193..3504 + 312 WP_001259758.1 colicin V -
PS034_RS23495 (3674) 3674..5770 - 2097 WP_021573924.1 peptidase domain-containing ABC transporter -
PS034_RS23500 (5763) 5763..7037 - 1275 WP_021573925.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - gspG / gspH / gspL / vat / bfpL / bfpK / bfpJ / bfpI / bfpH / bfpP / bfpF / bfpE / bfpD / bfpU / bfpC / bfpB / bfpG / bfpA 1..128726 128726


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T271940 WP_001384452.1 NZ_CP117660:2265-2543 [Escherichia albertii]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10224.57 Da        Isoelectric Point: 8.8735

>AT271940 WP_059272212.1 NZ_CP117660:1996-2265 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A828ANF7

References