Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3512375..3512993 Replicon chromosome
Accession NZ_CP117659
Organism Escherichia albertii strain BIA_13

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS034_RS17275 Protein ID WP_001280991.1
Coordinates 3512775..3512993 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS034_RS17270 Protein ID WP_000344798.1
Coordinates 3512375..3512749 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS034_RS17260 (3507455) 3507455..3508648 + 1194 WP_273822103.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS034_RS17265 (3508671) 3508671..3511820 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS034_RS17270 (3512375) 3512375..3512749 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS034_RS17275 (3512775) 3512775..3512993 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS034_RS17280 (3513170) 3513170..3513727 + 558 WP_025237467.1 maltose O-acetyltransferase -
PS034_RS17285 (3513834) 3513834..3514304 + 471 WP_000136188.1 YlaC family protein -
PS034_RS17290 (3514468) 3514468..3516018 + 1551 WP_001260378.1 EAL domain-containing protein -
PS034_RS17295 (3516056) 3516056..3516409 - 354 WP_000878151.1 DUF1428 family protein -
PS034_RS17305 (3516790) 3516790..3517101 + 312 WP_000409915.1 MGMT family protein -
PS034_RS17310 (3517131) 3517131..3517703 - 573 WP_059234328.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271931 WP_001280991.1 NZ_CP117659:3512775-3512993 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271931 WP_000344798.1 NZ_CP117659:3512375-3512749 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References