Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 890028..890679 Replicon chromosome
Accession NZ_CP117659
Organism Escherichia albertii strain BIA_13

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS034_RS04345 Protein ID WP_000244763.1
Coordinates 890275..890679 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS034_RS04340 Protein ID WP_000354046.1
Coordinates 890028..890294 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS034_RS04315 (885740) 885740..887173 - 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -
PS034_RS04320 (887218) 887218..887529 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS034_RS04325 (887697) 887697..888356 + 660 WP_000250281.1 hemolysin III family protein -
PS034_RS04330 (888796) 888796..889776 - 981 WP_000886057.1 tRNA-modifying protein YgfZ -
PS034_RS04335 (889808) 889808..890038 + 231 WP_000181267.1 hypothetical protein -
PS034_RS04340 (890028) 890028..890294 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS034_RS04345 (890275) 890275..890679 + 405 WP_000244763.1 protein YgfX Toxin
PS034_RS04350 (890718) 890718..891239 - 522 WP_059221135.1 flavodoxin FldB -
PS034_RS04355 (891351) 891351..892247 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS034_RS04360 (892272) 892272..892982 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS034_RS04365 (892988) 892988..894721 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271922 WP_000244763.1 NZ_CP117659:890275-890679 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271922 WP_000354046.1 NZ_CP117659:890028-890294 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References