Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 53507..54108 Replicon plasmid pEA15_2
Accession NZ_CP117656
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag PS036_RS24760 Protein ID WP_001216034.1
Coordinates 53507..53887 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag PS036_RS24765 Protein ID WP_001190712.1
Coordinates 53887..54108 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS24735 (PS036_24735) 49183..50376 - 1194 WP_273811299.1 terminase -
PS036_RS24740 (PS036_24740) 50442..51653 - 1212 WP_124866782.1 RNA-guided endonuclease TnpB family protein -
PS036_RS24745 (PS036_24745) 51696..52163 - 468 WP_059257205.1 hypothetical protein -
PS036_RS24750 (PS036_24750) 52252..53295 - 1044 WP_059257204.1 DUF968 domain-containing protein -
PS036_RS24755 (PS036_24755) 53323..53502 - 180 WP_000113018.1 hypothetical protein -
PS036_RS24760 (PS036_24760) 53507..53887 - 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS036_RS24765 (PS036_24765) 53887..54108 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS036_RS24770 (PS036_24770) 54291..55847 + 1557 WP_059257212.1 type I restriction-modification system subunit M -
PS036_RS24775 (PS036_24775) 55844..57079 + 1236 WP_059257202.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..98591 98591
- flank IS/Tn - - 50442..51593 1151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T271916 WP_001216034.1 NZ_CP117656:c53887-53507 [Escherichia albertii]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT271916 WP_001190712.1 NZ_CP117656:c54108-53887 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References