Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 78779..79404 Replicon plasmid pEA15_1
Accession NZ_CP117655
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS036_RS24120 Protein ID WP_000911317.1
Coordinates 79006..79404 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PS036_RS24115 Protein ID WP_059277990.1
Coordinates 78779..79006 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS24115 (78779) 78779..79006 + 228 WP_059277990.1 toxin-antitoxin system antitoxin VapB Antitoxin
PS036_RS24120 (79006) 79006..79404 + 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
PS036_RS24125 (79413) 79413..80660 - 1248 Protein_81 type IV secretion system DNA-binding domain-containing protein -
PS036_RS24130 (80690) 80690..82261 - 1572 WP_273810715.1 IS66 family transposase -
PS036_RS24135 (82281) 82281..82628 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
PS036_RS24140 (82628) 82628..83305 - 678 WP_001339397.1 IS66-like element accessory protein TnpA -
PS036_RS24145 (83359) 83359..84273 - 915 Protein_85 type IV secretion system DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 / espL2 / vat 1..130064 130064


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-40)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T271912 WP_000911317.1 NZ_CP117655:79006-79404 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8505.56 Da        Isoelectric Point: 4.7513

>AT271912 WP_059277990.1 NZ_CP117655:78779-79006 [Escherichia albertii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRARIITPAGETWDEWFDGHSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References