Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 43484..44127 Replicon plasmid pEA15_1
Accession NZ_CP117655
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag PS036_RS23955 Protein ID WP_053884725.1
Coordinates 43711..44127 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5Z7X8E3
Locus tag PS036_RS23950 Protein ID WP_001644959.1
Coordinates 43484..43714 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS23920 (38919) 38919..39632 - 714 WP_072244077.1 putative DNA-binding domain-containing protein -
PS036_RS23925 (39607) 39607..40458 - 852 WP_059278008.1 DUF692 domain-containing protein -
PS036_RS23930 (40446) 40446..40763 - 318 WP_059278007.1 hypothetical protein -
PS036_RS23935 (40767) 40767..41717 - 951 WP_059257123.1 MBL fold metallo-hydrolase -
PS036_RS23940 (42422) 42422..42988 - 567 WP_059278006.1 MarC family protein -
PS036_RS23945 (43072) 43072..43197 + 126 WP_273811202.1 hypothetical protein -
PS036_RS23950 (43484) 43484..43714 + 231 WP_001644959.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PS036_RS23955 (43711) 43711..44127 + 417 WP_053884725.1 type II toxin-antitoxin system VapC family toxin Toxin
PS036_RS23960 (44283) 44283..45092 + 810 WP_059278005.1 class I SAM-dependent methyltransferase -
PS036_RS23965 (45258) 45258..45398 - 141 WP_273811229.1 PapB/FocB family fimbrial expression transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 / espL2 / vat 1..130064 130064


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15079.42 Da        Isoelectric Point: 7.8874

>T271906 WP_053884725.1 NZ_CP117655:43711-44127 [Escherichia albertii]
VNKTYMLDTNICSFIMREQPEAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPNLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8706.80 Da        Isoelectric Point: 4.4692

>AT271906 WP_001644959.1 NZ_CP117655:43484-43714 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFLVEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7X8E3

References