Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3512696..3513314 Replicon chromosome
Accession NZ_CP117654
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS036_RS17515 Protein ID WP_001280991.1
Coordinates 3513096..3513314 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS036_RS17510 Protein ID WP_000344798.1
Coordinates 3512696..3513070 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS17500 (3507776) 3507776..3508969 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS036_RS17505 (3508992) 3508992..3512141 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS036_RS17510 (3512696) 3512696..3513070 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS036_RS17515 (3513096) 3513096..3513314 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS036_RS17520 (3513491) 3513491..3514048 + 558 WP_059221620.1 maltose O-acetyltransferase -
PS036_RS17525 (3514156) 3514156..3514626 + 471 WP_000136188.1 YlaC family protein -
PS036_RS17530 (3514790) 3514790..3516340 + 1551 WP_001260378.1 EAL domain-containing protein -
PS036_RS17535 (3516378) 3516378..3516548 - 171 Protein_3421 DUF1428 family protein -
PS036_RS17540 (3516605) 3516605..3517282 + 678 WP_001339397.1 IS66-like element accessory protein TnpA -
PS036_RS17545 (3517282) 3517282..3517629 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271902 WP_001280991.1 NZ_CP117654:3513096-3513314 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271902 WP_000344798.1 NZ_CP117654:3512696-3513070 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References