Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 893058..893709 Replicon chromosome
Accession NZ_CP117654
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS036_RS04320 Protein ID WP_000244763.1
Coordinates 893305..893709 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS036_RS04315 Protein ID WP_000354046.1
Coordinates 893058..893324 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS04285 (888068) 888068..888961 + 894 WP_059221140.1 transporter -
PS036_RS04290 (889008) 889008..890441 - 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -
PS036_RS04295 (890486) 890486..890797 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS036_RS04300 (890965) 890965..891624 + 660 WP_000250281.1 hemolysin III family protein -
PS036_RS04305 (891826) 891826..892806 - 981 WP_059221136.1 tRNA-modifying protein YgfZ -
PS036_RS04310 (892838) 892838..893068 + 231 WP_000181267.1 hypothetical protein -
PS036_RS04315 (893058) 893058..893324 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS036_RS04320 (893305) 893305..893709 + 405 WP_000244763.1 protein YgfX Toxin
PS036_RS04325 (893748) 893748..894269 - 522 WP_273810835.1 flavodoxin FldB -
PS036_RS04330 (894381) 894381..895277 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS036_RS04335 (895302) 895302..896012 + 711 WP_059275564.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS036_RS04340 (896018) 896018..897751 + 1734 WP_059221131.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271890 WP_000244763.1 NZ_CP117654:893305-893709 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271890 WP_000354046.1 NZ_CP117654:893058-893324 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References