Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 293656..294456 Replicon chromosome
Accession NZ_CP117654
Organism Escherichia albertii strain BIA_15

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag PS036_RS01365 Protein ID WP_273810814.1
Coordinates 293929..294456 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS036_RS01360 Protein ID WP_001277106.1
Coordinates 293656..293922 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS036_RS01340 (289312) 289312..289980 + 669 WP_000617720.1 cell division ATP-binding protein FtsE -
PS036_RS01345 (289973) 289973..291031 + 1059 WP_001042000.1 permease-like cell division protein FtsX -
PS036_RS01350 (291276) 291276..292130 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PS036_RS01355 (292403) 292403..293506 + 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS036_RS01360 (293656) 293656..293922 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS036_RS01365 (293929) 293929..294456 + 528 WP_273810814.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS036_RS01370 (294453) 294453..294836 - 384 WP_059220922.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS036_RS01375 (295260) 295260..296369 + 1110 WP_059220920.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS036_RS01380 (296417) 296417..297343 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS036_RS01385 (297340) 297340..298617 + 1278 WP_059275495.1 branched chain amino acid ABC transporter permease LivM -
PS036_RS01390 (298614) 298614..299381 + 768 WP_000083515.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19502.43 Da        Isoelectric Point: 6.6303

>T271889 WP_273810814.1 NZ_CP117654:293929-294456 [Escherichia albertii]
MDDLTIEILTDDADYDLQRLDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVILGRLAIDRSLQGQGWGATLVAHAMKVVCSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271889 WP_001277106.1 NZ_CP117654:293656-293922 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References