Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4791..5392 Replicon plasmid pEA16-1_1
Accession NZ_CP117651
Organism Escherichia albertii strain BIA_16-1

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag PS055_RS22265 Protein ID WP_001216045.1
Coordinates 5012..5392 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag PS055_RS22260 Protein ID WP_059222009.1
Coordinates 4791..5012 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS055_RS22250 (PS055_22250) 1835..3055 - 1221 WP_148880112.1 restriction endonuclease subunit S -
PS055_RS22255 (PS055_22255) 3052..4608 - 1557 WP_059222023.1 type I restriction-modification system subunit M -
PS055_RS22260 (PS055_22260) 4791..5012 + 222 WP_059222009.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PS055_RS22265 (PS055_22265) 5012..5392 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS055_RS22270 (PS055_22270) 5397..5576 + 180 WP_059222008.1 hypothetical protein -
PS055_RS22275 (PS055_22275) 5604..6647 + 1044 WP_059222007.1 DUF968 domain-containing protein -
PS055_RS22280 (PS055_22280) 6736..7188 + 453 WP_032165150.1 Late promoter-activating protein -
PS055_RS22285 (PS055_22285) 7225..8400 - 1176 WP_000942666.1 RNA-guided endonuclease TnpB family protein -
PS055_RS22290 (PS055_22290) 8608..9801 + 1194 WP_059222006.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99447 99447
- flank IS/Tn - - 7225..8400 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T271885 WP_001216045.1 NZ_CP117651:5012-5392 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8135.11 Da        Isoelectric Point: 4.7708

>AT271885 WP_059222009.1 NZ_CP117651:4791-5012 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEIIRRGRESAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure

References