Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4152620..4153238 Replicon chromosome
Accession NZ_CP117650
Organism Escherichia albertii strain BIA_16-1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS055_RS20175 Protein ID WP_001280991.1
Coordinates 4152620..4152838 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS055_RS20180 Protein ID WP_000344798.1
Coordinates 4152864..4153238 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS055_RS20140 (4147909) 4147909..4148481 + 573 WP_000779847.1 YbaY family lipoprotein -
PS055_RS20145 (4148511) 4148511..4148822 - 312 WP_000409915.1 MGMT family protein -
PS055_RS20155 (4149203) 4149203..4149556 + 354 WP_000878151.1 DUF1428 family protein -
PS055_RS20160 (4149594) 4149594..4151144 - 1551 WP_059221618.1 EAL domain-containing protein -
PS055_RS20165 (4151308) 4151308..4151778 - 471 WP_000136188.1 YlaC family protein -
PS055_RS20170 (4151886) 4151886..4152443 - 558 WP_059221620.1 maltose O-acetyltransferase -
PS055_RS20175 (4152620) 4152620..4152838 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS055_RS20180 (4152864) 4152864..4153238 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS055_RS20185 (4153793) 4153793..4156942 - 3150 WP_059221622.1 efflux RND transporter permease AcrB -
PS055_RS20190 (4156965) 4156965..4158158 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271884 WP_001280991.1 NZ_CP117650:c4152838-4152620 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271884 WP_000344798.1 NZ_CP117650:c4153238-4152864 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References