Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2663668..2664468 Replicon chromosome
Accession NZ_CP117650
Organism Escherichia albertii strain BIA_16-1

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag PS055_RS13100 Protein ID WP_059220924.1
Coordinates 2663668..2664195 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS055_RS13105 Protein ID WP_001277106.1
Coordinates 2664202..2664468 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS055_RS13075 (2658743) 2658743..2659510 - 768 WP_000083515.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PS055_RS13080 (2659507) 2659507..2660784 - 1278 WP_059220918.1 branched chain amino acid ABC transporter permease LivM -
PS055_RS13085 (2660781) 2660781..2661707 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS055_RS13090 (2661755) 2661755..2662864 - 1110 WP_059220920.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS055_RS13095 (2663288) 2663288..2663671 + 384 WP_059220922.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS055_RS13100 (2663668) 2663668..2664195 - 528 WP_059220924.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS055_RS13105 (2664202) 2664202..2664468 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS055_RS13110 (2664618) 2664618..2665721 - 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS055_RS13115 (2665994) 2665994..2666848 - 855 WP_059220926.1 RNA polymerase sigma factor RpoH -
PS055_RS13120 (2667093) 2667093..2668151 - 1059 WP_001042000.1 permease-like cell division protein FtsX -
PS055_RS13125 (2668144) 2668144..2668812 - 669 WP_000617720.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19490.38 Da        Isoelectric Point: 6.6303

>T271879 WP_059220924.1 NZ_CP117650:c2664195-2663668 [Escherichia albertii]
MDDLTIEILTDDADYDLQRLDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVCSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271879 WP_001277106.1 NZ_CP117650:c2664468-2664202 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References