Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2075775..2076426 Replicon chromosome
Accession NZ_CP117650
Organism Escherichia albertii strain BIA_16-1

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS055_RS10185 Protein ID WP_000244763.1
Coordinates 2075775..2076179 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS055_RS10190 Protein ID WP_000354046.1
Coordinates 2076160..2076426 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS055_RS10165 (2071733) 2071733..2073466 - 1734 WP_059221131.1 single-stranded-DNA-specific exonuclease RecJ -
PS055_RS10170 (2073472) 2073472..2074182 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS055_RS10175 (2074207) 2074207..2075103 - 897 WP_059221133.1 site-specific tyrosine recombinase XerD -
PS055_RS10180 (2075215) 2075215..2075736 + 522 WP_059221135.1 flavodoxin FldB -
PS055_RS10185 (2075775) 2075775..2076179 - 405 WP_000244763.1 protein YgfX Toxin
PS055_RS10190 (2076160) 2076160..2076426 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS055_RS10195 (2076416) 2076416..2076646 - 231 WP_000181267.1 hypothetical protein -
PS055_RS10200 (2076678) 2076678..2077658 + 981 WP_059221136.1 tRNA-modifying protein YgfZ -
PS055_RS10205 (2077860) 2077860..2078519 - 660 WP_000250281.1 hemolysin III family protein -
PS055_RS10210 (2078687) 2078687..2078998 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS055_RS10215 (2079043) 2079043..2080476 + 1434 WP_059221179.1 6-phospho-beta-glucosidase BglA -
PS055_RS10220 (2080523) 2080523..2081416 - 894 WP_059221140.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271878 WP_000244763.1 NZ_CP117650:c2076179-2075775 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271878 WP_000354046.1 NZ_CP117650:c2076426-2076160 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References