Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 669759..670363 Replicon chromosome
Accession NZ_CP117650
Organism Escherichia albertii strain BIA_16-1

Toxin (Protein)


Gene name doc Uniprot ID A0A8H9B4D1
Locus tag PS055_RS03230 Protein ID WP_059222236.1
Coordinates 669759..670145 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS055_RS03235 Protein ID WP_001195490.1
Coordinates 670142..670363 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS055_RS03230 (669759) 669759..670145 - 387 WP_059222236.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS055_RS03235 (670142) 670142..670363 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS055_RS03240 (670781) 670781..671329 + 549 Protein_640 trans-aconitate 2-methyltransferase -
PS055_RS03245 (671329) 671329..671583 - 255 Protein_641 bestrophin family ion channel -
PS055_RS03250 (671788) 671788..673239 - 1452 WP_059220135.1 tagaturonate reductase -
PS055_RS03255 (673486) 673486..674904 - 1419 WP_000558269.1 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14475.47 Da        Isoelectric Point: 8.0833

>T271872 WP_059222236.1 NZ_CP117650:c670145-669759 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLADPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271872 WP_001195490.1 NZ_CP117650:c670363-670142 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References