Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 58200..58747 Replicon plasmid pEA16-3_1
Accession NZ_CP117648
Organism Escherichia albertii strain BIA_16-3

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PS048_RS23920 Protein ID WP_262939943.1
Coordinates 58469..58747 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A828ANF7
Locus tag PS048_RS23915 Protein ID WP_059272212.1
Coordinates 58200..58469 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS048_RS23890 (54786) 54786..55088 + 303 WP_072146426.1 DUF1778 domain-containing protein -
PS048_RS23895 (55079) 55079..55561 + 483 WP_059257273.1 GNAT family N-acetyltransferase -
PS048_RS23900 (55872) 55872..56126 + 255 WP_273786639.1 replication regulatory protein RepA -
PS048_RS23905 (56362) 56362..56436 + 75 WP_001375168.1 RepA leader peptide Tap -
PS048_RS23910 (56429) 56429..57286 + 858 WP_265463468.1 incFII family plasmid replication initiator RepA -
PS048_RS23915 (58200) 58200..58469 + 270 WP_059272212.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PS048_RS23920 (58469) 58469..58747 + 279 WP_262939943.1 type II toxin-antitoxin system toxin YacB Toxin
PS048_RS23925 (58793) 58793..59346 + 554 Protein_68 3'-5' exonuclease -
PS048_RS23930 (59632) 59632..59997 - 366 WP_262933613.1 hypothetical protein -
PS048_RS23935 (60510) 60510..61209 + 700 Protein_70 ISL3 family transposase -
PS048_RS23940 (61259) 61259..61849 - 591 WP_273785352.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82983 82983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10691.29 Da        Isoelectric Point: 7.2749

>T271870 WP_262939943.1 NZ_CP117648:58469-58747 [Escherichia albertii]
MEIFWTILASQDRKCIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10224.57 Da        Isoelectric Point: 8.8735

>AT271870 WP_059272212.1 NZ_CP117648:58200-58469 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ANF7

References