Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 42573..43198 Replicon plasmid pEA16-3_1
Accession NZ_CP117648
Organism Escherichia albertii strain BIA_16-3

Toxin (Protein)


Gene name vapC Uniprot ID A0A828AN07
Locus tag PS048_RS23835 Protein ID WP_059257082.1
Coordinates 42573..42971 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8H9EG71
Locus tag PS048_RS23840 Protein ID WP_000450526.1
Coordinates 42971..43198 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS048_RS23820 (38827) 38827..39135 - 309 WP_059257085.1 heavy metal-binding domain-containing protein -
PS048_RS23825 (39349) 39349..40041 + 693 WP_273786688.1 hypothetical protein -
PS048_RS23830 (40357) 40357..42564 + 2208 WP_273786690.1 type IV conjugative transfer system coupling protein TraD -
PS048_RS23835 (42573) 42573..42971 - 399 WP_059257082.1 tRNA(fMet)-specific endonuclease VapC Toxin
PS048_RS23840 (42971) 42971..43198 - 228 WP_000450526.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82983 82983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14945.27 Da        Isoelectric Point: 7.8605

>T271864 WP_059257082.1 NZ_CP117648:c42971-42573 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNIREFERMDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.53 Da        Isoelectric Point: 4.5358

>AT271864 WP_000450526.1 NZ_CP117648:c43198-42971 [Escherichia albertii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828AN07

Antitoxin

Source ID Structure

References