Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4043741..4044317 Replicon chromosome
Accession NZ_CP117647
Organism Escherichia albertii strain BIA_16-3

Toxin (Protein)


Gene name shpA Uniprot ID A0A0K4FW98
Locus tag PS048_RS19825 Protein ID WP_044708725.1
Coordinates 4044030..4044317 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0K4FU62
Locus tag PS048_RS19820 Protein ID WP_054409941.1
Coordinates 4043741..4044043 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS048_RS19795 (4039362) 4039362..4039493 - 132 WP_024164650.1 hypothetical protein -
PS048_RS19800 (4039511) 4039511..4039815 - 305 Protein_3866 Tar ligand binding domain-containing protein -
PS048_RS19805 (4040337) 4040337..4042487 + 2151 WP_273785046.1 pyruvate/proton symporter BtsT -
PS048_RS19810 (4042537) 4042537..4042740 + 204 WP_000467859.1 YbdD/YjiX family protein -
PS048_RS19815 (4042751) 4042751..4043707 + 957 WP_002430330.1 GTPase -
PS048_RS19820 (4043741) 4043741..4044043 - 303 WP_054409941.1 BrnA antitoxin family protein Antitoxin
PS048_RS19825 (4044030) 4044030..4044317 - 288 WP_044708725.1 BrnT family toxin Toxin
PS048_RS19830 (4044514) 4044514..4045680 + 1167 WP_000800832.1 restriction endonuclease -
PS048_RS19835 (4045744) 4045744..4047363 + 1620 Protein_3873 class I SAM-dependent DNA methyltransferase -
PS048_RS19840 (4047353) 4047353..4048711 + 1359 WP_273785054.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11155.59 Da        Isoelectric Point: 6.9903

>T271859 WP_044708725.1 NZ_CP117647:c4044317-4044030 [Escherichia albertii]
MPMEFEWDANKAKSNQVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.04 Da        Isoelectric Point: 9.4646

>AT271859 WP_054409941.1 NZ_CP117647:c4044043-4043741 [Escherichia albertii]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEEIDYSDIPPSSDELWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4FW98

Antitoxin

Source ID Structure
AlphaFold DB A0A0K4FU62

References