Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3498684..3499302 Replicon chromosome
Accession NZ_CP117647
Organism Escherichia albertii strain BIA_16-3

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS048_RS17235 Protein ID WP_001280991.1
Coordinates 3499084..3499302 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS048_RS17230 Protein ID WP_000344798.1
Coordinates 3498684..3499058 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS048_RS17220 (3493764) 3493764..3494957 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS048_RS17225 (3494980) 3494980..3498129 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS048_RS17230 (3498684) 3498684..3499058 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS048_RS17235 (3499084) 3499084..3499302 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS048_RS17240 (3499479) 3499479..3500036 + 558 WP_137648729.1 maltose O-acetyltransferase -
PS048_RS17245 (3500144) 3500144..3500614 + 471 WP_000136188.1 YlaC family protein -
PS048_RS17250 (3500778) 3500778..3502328 + 1551 WP_137648730.1 EAL domain-containing protein -
PS048_RS17255 (3502366) 3502366..3502719 - 354 WP_000878151.1 DUF1428 family protein -
PS048_RS17265 (3503100) 3503100..3503411 + 312 WP_000409915.1 MGMT family protein -
PS048_RS17270 (3503441) 3503441..3504013 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271856 WP_001280991.1 NZ_CP117647:3499084-3499302 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271856 WP_000344798.1 NZ_CP117647:3498684-3499058 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References