Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 936511..937162 Replicon chromosome
Accession NZ_CP117647
Organism Escherichia albertii strain BIA_16-3

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS048_RS04535 Protein ID WP_000244763.1
Coordinates 936758..937162 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS048_RS04530 Protein ID WP_000354046.1
Coordinates 936511..936777 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS048_RS04505 (932223) 932223..933656 - 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -
PS048_RS04510 (933701) 933701..934012 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS048_RS04515 (934180) 934180..934839 + 660 WP_000250281.1 hemolysin III family protein -
PS048_RS04520 (935279) 935279..936259 - 981 WP_103053871.1 tRNA-modifying protein YgfZ -
PS048_RS04525 (936291) 936291..936521 + 231 WP_000181267.1 hypothetical protein -
PS048_RS04530 (936511) 936511..936777 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS048_RS04535 (936758) 936758..937162 + 405 WP_000244763.1 protein YgfX Toxin
PS048_RS04540 (937201) 937201..937722 - 522 WP_059235395.1 flavodoxin FldB -
PS048_RS04545 (937834) 937834..938730 + 897 WP_059228147.1 site-specific tyrosine recombinase XerD -
PS048_RS04550 (938755) 938755..939465 + 711 WP_273785785.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS048_RS04555 (939471) 939471..941204 + 1734 WP_273785787.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271847 WP_000244763.1 NZ_CP117647:936758-937162 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271847 WP_000354046.1 NZ_CP117647:936511-936777 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References