Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1995..2542 Replicon plasmid pEA17_2
Accession NZ_CP117645
Organism Escherichia albertii strain BIA_17

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag PS043_RS24995 Protein ID WP_001384452.1
Coordinates 2264..2542 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U8WKC6
Locus tag PS043_RS24990 Protein ID WP_000079946.1
Coordinates 1995..2264 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS043_RS24985 (46) 46..1077 + 1032 WP_273817157.1 plasmid replication initiator RepA -
PS043_RS24990 (1995) 1995..2264 + 270 WP_000079946.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PS043_RS24995 (2264) 2264..2542 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
PS043_RS25000 (2588) 2588..3436 + 849 WP_021500351.1 3'-5' exonuclease -
PS043_RS25005 (3553) 3553..4035 + 483 WP_001311056.1 hypothetical protein -
PS043_RS25010 (4336) 4336..4683 + 348 WP_273817145.1 DUF6404 family protein -
PS043_RS25015 (4703) 4703..5293 - 591 WP_100028673.1 hypothetical protein -
PS043_RS25020 (5293) 5293..5550 - 258 WP_000343099.1 hypothetical protein -
PS043_RS25025 (6120) 6120..6533 + 414 WP_000465041.1 hypothetical protein -
PS043_RS25030 (6535) 6535..7317 + 783 WP_273817146.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - bfpL / bfpK / bfpJ / bfpI / bfpH / bfpP / bfpF / bfpE / bfpD / bfpU / bfpC / bfpB / bfpG / bfpA 1..77860 77860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T271839 WP_001384452.1 NZ_CP117645:2264-2542 [Escherichia albertii]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10210.55 Da        Isoelectric Point: 8.8735

>AT271839 WP_000079946.1 NZ_CP117645:1995-2264 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8WKC6

References