Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 79408..80033 Replicon plasmid pEA17_1
Accession NZ_CP117644
Organism Escherichia albertii strain BIA_17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS043_RS24725 Protein ID WP_273817105.1
Coordinates 79408..79806 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag PS043_RS24730 Protein ID WP_000450520.1
Coordinates 79806..80033 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS043_RS24710 (75733) 75733..76230 + 498 WP_273817104.1 entry exclusion protein -
PS043_RS24715 (76262) 76262..76993 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
PS043_RS24720 (77246) 77246..79399 + 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
PS043_RS24725 (79408) 79408..79806 - 399 WP_273817105.1 tRNA(fMet)-specific endonuclease VapC Toxin
PS043_RS24730 (79806) 79806..80033 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sitABCD spvC / spvC / spvC / spvC / espK / nleA/espI / vat / iutA / iucD / iucC / iucB / iucA 1..132593 132593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14917.15 Da        Isoelectric Point: 7.8605

>T271837 WP_273817105.1 NZ_CP117644:c79806-79408 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHSRSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT271837 WP_000450520.1 NZ_CP117644:c80033-79806 [Escherichia albertii]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References