Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3530973..3531591 Replicon chromosome
Accession NZ_CP117643
Organism Escherichia albertii strain BIA_17

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS043_RS17800 Protein ID WP_001280991.1
Coordinates 3531373..3531591 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS043_RS17795 Protein ID WP_000344798.1
Coordinates 3530973..3531347 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS043_RS17785 (3526053) 3526053..3527246 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS043_RS17790 (3527269) 3527269..3530418 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS043_RS17795 (3530973) 3530973..3531347 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS043_RS17800 (3531373) 3531373..3531591 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS043_RS17805 (3531768) 3531768..3532325 + 558 WP_025237467.1 maltose O-acetyltransferase -
PS043_RS17810 (3532432) 3532432..3532902 + 471 WP_000136188.1 YlaC family protein -
PS043_RS17815 (3533066) 3533066..3534616 + 1551 WP_001260378.1 EAL domain-containing protein -
PS043_RS17820 (3534654) 3534654..3535007 - 354 WP_000878151.1 DUF1428 family protein -
PS043_RS17830 (3535388) 3535388..3535699 + 312 WP_000409915.1 MGMT family protein -
PS043_RS17835 (3535729) 3535729..3536301 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271826 WP_001280991.1 NZ_CP117643:3531373-3531591 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271826 WP_000344798.1 NZ_CP117643:3530973-3531347 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References