Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1979218..1979808 Replicon chromosome
Accession NZ_CP117643
Organism Escherichia albertii strain BIA_17

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag PS043_RS09910 Protein ID WP_059225520.1
Coordinates 1979476..1979808 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag PS043_RS09905 Protein ID WP_059225519.1
Coordinates 1979218..1979475 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS043_RS09885 (1975780) 1975780..1976477 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
PS043_RS09890 (1976488) 1976488..1977597 - 1110 WP_273816966.1 hypothetical protein -
PS043_RS09895 (1978198) 1978198..1978668 + 471 WP_059225518.1 hypothetical protein -
PS043_RS09900 (1978665) 1978665..1978870 + 206 Protein_1936 helix-turn-helix transcriptional regulator -
PS043_RS09905 (1979218) 1979218..1979475 + 258 WP_059225519.1 hypothetical protein Antitoxin
PS043_RS09910 (1979476) 1979476..1979808 + 333 WP_059225520.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PS043_RS09915 (1979921) 1979921..1980298 + 378 WP_273816967.1 hypothetical protein -
PS043_RS09920 (1980616) 1980616..1981500 + 885 WP_059225521.1 integrase domain-containing protein -
PS043_RS09925 (1981596) 1981596..1981883 - 288 WP_059225522.1 hypothetical protein -
PS043_RS09930 (1982096) 1982096..1982224 - 129 WP_273816968.1 hypothetical protein -
PS043_RS09935 (1982842) 1982842..1984104 - 1263 WP_059225524.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rhs/PAAR 1951928..1999269 47341


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11777.59 Da        Isoelectric Point: 8.0291

>T271819 WP_059225520.1 NZ_CP117643:1979476-1979808 [Escherichia albertii]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSPASFNEVTRLPVIVPVTSGGQFARSAGFAVSLEGAGTKTTGIIRCDQPRTI
DMGARNGKRLERIPDGIINEVLARLETILA

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9314.80 Da        Isoelectric Point: 4.4488

>AT271819 WP_059225519.1 NZ_CP117643:1979218-1979475 [Escherichia albertii]
MYTTRLKKVGGSVMLAVPPAVLKTLALLPDSEVGVTIDNGCLIIEPQKRPRYSLAELLAQCDPHEEISDEEREWIDAPAA
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References