Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 910714..911365 Replicon chromosome
Accession NZ_CP117643
Organism Escherichia albertii strain BIA_17

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag PS043_RS04520 Protein ID WP_161537425.1
Coordinates 910961..911365 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS043_RS04515 Protein ID WP_000354046.1
Coordinates 910714..910980 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS043_RS04490 (906425) 906425..907858 - 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -
PS043_RS04495 (907903) 907903..908214 + 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
PS043_RS04500 (908382) 908382..909041 + 660 WP_000250281.1 hemolysin III family protein -
PS043_RS04505 (909482) 909482..910462 - 981 WP_125060505.1 tRNA-modifying protein YgfZ -
PS043_RS04510 (910494) 910494..910724 + 231 WP_000181267.1 hypothetical protein -
PS043_RS04515 (910714) 910714..910980 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS043_RS04520 (910961) 910961..911365 + 405 WP_161537425.1 protein YgfX Toxin
PS043_RS04525 (911404) 911404..911925 - 522 WP_161537424.1 flavodoxin FldB -
PS043_RS04530 (912037) 912037..912933 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS043_RS04535 (912958) 912958..913668 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS043_RS04540 (913674) 913674..915407 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15819.70 Da        Isoelectric Point: 10.7510

>T271817 WP_161537425.1 NZ_CP117643:910961-911365 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271817 WP_000354046.1 NZ_CP117643:910714-910980 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References