Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1996..2543 Replicon plasmid pEA18_3
Accession NZ_CP117640
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PS040_RS25345 Protein ID WP_273784138.1
Coordinates 2265..2543 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag PS040_RS25340 Protein ID WP_000079941.1
Coordinates 1996..2265 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS25330 (46) 46..1077 + 1032 WP_273784125.1 plasmid replication initiator RepA -
PS040_RS25335 (1783) 1783..1941 + 159 WP_165387335.1 hypothetical protein -
PS040_RS25340 (1996) 1996..2265 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PS040_RS25345 (2265) 2265..2543 + 279 WP_273784138.1 type II toxin-antitoxin system toxin YacB Toxin
PS040_RS25350 (2852) 2852..3994 + 1143 WP_158649904.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
PS040_RS25355 (3967) 3967..4071 + 105 Protein_5 hypothetical protein -
PS040_RS25360 (4083) 4083..4994 + 912 WP_024244186.1 toll/interleukin-1 receptor domain-containing protein -
PS040_RS25365 (5136) 5136..5531 - 396 WP_000445930.1 plasmid partitioning/stability family protein -
PS040_RS25370 (5531) 5531..6490 - 960 WP_000921958.1 plasmid segregation protein ParM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - bfpL / bfpK / bfpJ / bfpI / bfpH / bfpP / bfpF / bfpE / bfpD / bfpU / bfpC / bfpB / bfpG / bfpA 1..71004 71004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10760.34 Da        Isoelectric Point: 8.4615

>T271812 WP_273784138.1 NZ_CP117640:2265-2543 [Escherichia albertii]
MEIFWTMLASQDRKRIREYIAEQNLTVAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT271812 WP_000079941.1 NZ_CP117640:1996-2265 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References