Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4370270..4371968 Replicon chromosome
Accession NZ_CP117637
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag PS040_RS21600 Protein ID WP_273782486.1
Coordinates 4371039..4371968 (+) Length 310 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag PS040_RS21595 Protein ID WP_024165421.1
Coordinates 4370270..4371052 (+) Length 261 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS21565 (4365300) 4365300..4365851 + 552 WP_273782482.1 hypothetical protein -
PS040_RS21570 (4365854) 4365854..4366342 + 489 WP_273782483.1 DUF6521 family protein -
PS040_RS21575 (4366339) 4366339..4366878 + 540 WP_273782484.1 hypothetical protein -
PS040_RS21580 (4366894) 4366894..4368330 + 1437 WP_273782485.1 DUF3732 domain-containing protein -
PS040_RS21585 (4368411) 4368411..4369211 - 801 WP_000356512.1 hypothetical protein -
PS040_RS21590 (4369252) 4369252..4370121 - 870 WP_000547574.1 hypothetical protein -
PS040_RS21595 (4370270) 4370270..4371052 + 783 WP_024165421.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
PS040_RS21600 (4371039) 4371039..4371968 + 930 WP_273782486.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PS040_RS21605 (4373136) 4373136..4373414 - 279 WP_032279169.1 hypothetical protein -
PS040_RS21610 (4373472) 4373472..4374836 - 1365 WP_273782487.1 EspK/GogB family type III secretion system effector -
PS040_RS21615 (4375128) 4375128..4375766 - 639 WP_059258007.1 DUF1076 domain-containing protein -
PS040_RS21620 (4375964) 4375964..4376548 + 585 WP_273782488.1 bfpT-regulated chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - espK / espF / escG / escF / cesD2 / espB / espD / espA / sepL / escD / eae / cesT / tir / map / cesF / espH / sepQ/escQ / escO / escN / escV / cesL / sepZ/espZ / escI / escJ / sepD / escC / cesD / etgA / escU / escT / escS / escR / escL / escK / cesAB / escE / espG 4363926..4413007 49081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(12-261)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(96-247)


Sequences

Toxin        


Download         Length: 310 a.a.        Molecular weight: 35114.60 Da        Isoelectric Point: 6.4965

>T271808 WP_273782486.1 NZ_CP117637:4371039-4371968 [Escherichia albertii]
MDLRDSYARQVRLLMTVLPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADREADLAAINDALMRITESLNGR
AGITAIRQENKTDEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEMEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLVGHPRPIAELLAPNWDTPRIATLYAQEFSGMTQRETSLESLLSVTMLLPQAL
KSHLTDRDRQFLLSYKQNTPNWSLYRYPEIQHLPAIRWKLRNLAVLNDKNPAKFAAAVSKLEGVLEQYF

Download         Length: 930 bp

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29286.64 Da        Isoelectric Point: 8.4386

>AT271808 WP_024165421.1 NZ_CP117637:4370270-4371052 [Escherichia albertii]
MPNYLNWLMQNTLPGQVLLQSWLVRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGRQQVWLALAAYVKLPGWFVTFEQSVTFVTLYTSGLTVDVIPFTTKLNIGDRQLVGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPGGVEDGSA

Download         Length: 783 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References