Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3592341..3592959 Replicon chromosome
Accession NZ_CP117637
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS040_RS17850 Protein ID WP_001280991.1
Coordinates 3592741..3592959 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS040_RS17845 Protein ID WP_000344798.1
Coordinates 3592341..3592715 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS17835 (3587421) 3587421..3588614 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS040_RS17840 (3588637) 3588637..3591786 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS040_RS17845 (3592341) 3592341..3592715 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS040_RS17850 (3592741) 3592741..3592959 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS040_RS17855 (3593136) 3593136..3593693 + 558 WP_204628716.1 maltose O-acetyltransferase -
PS040_RS17860 (3593801) 3593801..3594271 + 471 WP_000136188.1 YlaC family protein -
PS040_RS17865 (3594435) 3594435..3595985 + 1551 WP_054411428.1 EAL domain-containing protein -
PS040_RS17870 (3596023) 3596023..3596376 - 354 WP_000878151.1 DUF1428 family protein -
PS040_RS17880 (3596757) 3596757..3597068 + 312 WP_000409915.1 MGMT family protein -
PS040_RS17885 (3597098) 3597098..3597670 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271801 WP_001280991.1 NZ_CP117637:3592741-3592959 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271801 WP_000344798.1 NZ_CP117637:3592341-3592715 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References