Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2510062..2510666 Replicon chromosome
Accession NZ_CP117637
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PS040_RS12530 Protein ID WP_273782133.1
Coordinates 2510280..2510666 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS040_RS12525 Protein ID WP_001195490.1
Coordinates 2510062..2510283 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS12505 (2505163) 2505163..2506800 + 1638 WP_273782131.1 hypothetical protein -
PS040_RS12510 (2506818) 2506818..2507105 + 288 WP_062863912.1 DUF2523 family protein -
PS040_RS12515 (2507117) 2507117..2508175 + 1059 WP_273782132.1 zonular occludens toxin domain-containing protein -
PS040_RS12520 (2508172) 2508172..2509431 + 1260 WP_062863914.1 type II secretion system protein GspD -
PS040_RS12525 (2510062) 2510062..2510283 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS040_RS12530 (2510280) 2510280..2510666 + 387 WP_273782133.1 type II toxin-antitoxin system death-on-curing family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-110)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14449.43 Da        Isoelectric Point: 9.0256

>T271799 WP_273782133.1 NZ_CP117637:2510280-2510666 [Escherichia albertii]
MIWVSAQEVIAFHARILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGTRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271799 WP_001195490.1 NZ_CP117637:2510062-2510283 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References