Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 892896..893547 Replicon chromosome
Accession NZ_CP117637
Organism Escherichia albertii strain BIA_18

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS040_RS04325 Protein ID WP_000244763.1
Coordinates 893143..893547 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS040_RS04320 Protein ID WP_000354046.1
Coordinates 892896..893162 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS040_RS04300 (888606) 888606..890039 - 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -
PS040_RS04305 (890084) 890084..890395 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS040_RS04310 (890563) 890563..891222 + 660 WP_000250281.1 hemolysin III family protein -
PS040_RS04315 (891663) 891663..892643 - 981 WP_273783069.1 tRNA-modifying protein YgfZ -
PS040_RS04320 (892896) 892896..893162 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS040_RS04325 (893143) 893143..893547 + 405 WP_000244763.1 protein YgfX Toxin
PS040_RS04330 (893586) 893586..894107 - 522 WP_273783070.1 flavodoxin FldB -
PS040_RS04335 (894219) 894219..895115 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS040_RS04340 (895140) 895140..895850 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS040_RS04345 (895856) 895856..897589 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271793 WP_000244763.1 NZ_CP117637:893143-893547 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271793 WP_000354046.1 NZ_CP117637:892896-893162 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References