Detailed information of TA system TA027179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3979752..3980566
• Replicon: chromosome
• Accession: NC_017625
• Organism: Escherichia coli DH1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: ECDH1_RS19680
• Protein ID: WP_001054376.1
• Coordinates: 3979752..3980009 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: ECDH1_RS19685
• Protein ID: WP_001309181.1
• Coordinates: 3980021..3980566 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECDH1_RS19655	3975040..3976146	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
ECDH1_RS19660	3976211..3977191	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
ECDH1_RS19665	3977774..3979014	-	1241	Protein_3748	helicase YjhR	-
ECDH1_RS25865	3979130..3979375	+	246	Protein_3749	GNAT family N-acetyltransferase	-
ECDH1_RS19680	3979752..3980009	+	258	WP_001054376.1	hypothetical protein	Toxin
ECDH1_RS19685	3980021..3980566	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
ECDH1_RS19690	3980622..3981368	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
ECDH1_RS25400	3981537..3981755	+	219	Protein_3753	hypothetical protein	-
ECDH1_RS26055	3981793..3981909	+	117	Protein_3754	VOC family protein	-
ECDH1_RS19695	3982154..3983275	+	1122	WP_000010829.1	M42 family metallopeptidase	-
ECDH1_RS19700	3983272..3983550	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
ECDH1_RS19705	3983562..3984875	+	1314	WP_000460842.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	3968762..3988790	20028

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T27179 WP_001054376.1 NC_017625:3979752-3980009 [Escherichia coli DH1]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T27179 NC_017625:3979752-3980009 [Escherichia coli DH1]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT27179 WP_001309181.1 NC_017625:3980021-3980566 [Escherichia coli DH1]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT27179 NC_017625:3980021-3980566 [Escherichia coli DH1]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8