Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3726744..3727395 Replicon chromosome
Accession NZ_CP117628
Organism Escherichia albertii strain BIA_22

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS041_RS18620 Protein ID WP_000244763.1
Coordinates 3726744..3727148 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS041_RS18625 Protein ID WP_000354046.1
Coordinates 3727129..3727395 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS041_RS18600 (3722707) 3722707..3724440 - 1734 WP_273785787.1 single-stranded-DNA-specific exonuclease RecJ -
PS041_RS18605 (3724446) 3724446..3725156 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS041_RS18610 (3725181) 3725181..3726077 - 897 WP_273824434.1 site-specific tyrosine recombinase XerD -
PS041_RS18615 (3726189) 3726189..3726710 + 522 WP_059221135.1 flavodoxin FldB -
PS041_RS18620 (3726744) 3726744..3727148 - 405 WP_000244763.1 protein YgfX Toxin
PS041_RS18625 (3727129) 3727129..3727395 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS041_RS18630 (3727385) 3727385..3727615 - 231 WP_000181267.1 hypothetical protein -
PS041_RS18635 (3727647) 3727647..3728627 + 981 WP_131109271.1 tRNA-modifying protein YgfZ -
PS041_RS18640 (3729068) 3729068..3729727 - 660 WP_000250281.1 hemolysin III family protein -
PS041_RS18645 (3729895) 3729895..3730206 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS041_RS18650 (3730251) 3730251..3731684 + 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271772 WP_000244763.1 NZ_CP117628:c3727148-3726744 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271772 WP_000354046.1 NZ_CP117628:c3727395-3727129 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References