Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1101071..1101689 Replicon chromosome
Accession NZ_CP117628
Organism Escherichia albertii strain BIA_22

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS041_RS05490 Protein ID WP_001280991.1
Coordinates 1101071..1101289 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS041_RS05495 Protein ID WP_000344798.1
Coordinates 1101315..1101689 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS041_RS05460 (1096964) 1096964..1097275 - 312 WP_000409915.1 MGMT family protein -
PS041_RS05470 (1097656) 1097656..1098008 + 353 Protein_1062 DUF1428 family protein -
PS041_RS05475 (1098046) 1098046..1099596 - 1551 WP_273825077.1 EAL domain-containing protein -
PS041_RS05480 (1099760) 1099760..1100230 - 471 WP_000136188.1 YlaC family protein -
PS041_RS05485 (1100337) 1100337..1100894 - 558 WP_025237467.1 maltose O-acetyltransferase -
PS041_RS05490 (1101071) 1101071..1101289 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS041_RS05495 (1101315) 1101315..1101689 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS041_RS05500 (1102244) 1102244..1105393 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS041_RS05505 (1105416) 1105416..1106609 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1095411..1096784 1373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271761 WP_001280991.1 NZ_CP117628:c1101289-1101071 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271761 WP_000344798.1 NZ_CP117628:c1101689-1101315 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References