Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3694142..3694793 Replicon chromosome
Accession NZ_CP117620
Organism Escherichia albertii strain BIA_24

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS039_RS17870 Protein ID WP_000244763.1
Coordinates 3694142..3694546 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS039_RS17875 Protein ID WP_000354046.1
Coordinates 3694527..3694793 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS039_RS17850 (3690100) 3690100..3691833 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
PS039_RS17855 (3691839) 3691839..3692549 - 711 WP_000748105.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS039_RS17860 (3692574) 3692574..3693470 - 897 WP_273809596.1 site-specific tyrosine recombinase XerD -
PS039_RS17865 (3693582) 3693582..3694103 + 522 WP_059235395.1 flavodoxin FldB -
PS039_RS17870 (3694142) 3694142..3694546 - 405 WP_000244763.1 protein YgfX Toxin
PS039_RS17875 (3694527) 3694527..3694793 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS039_RS17880 (3694783) 3694783..3695013 - 231 WP_273809598.1 hypothetical protein -
PS039_RS17885 (3695045) 3695045..3696025 + 981 WP_273809600.1 tRNA-modifying protein YgfZ -
PS039_RS17890 (3696466) 3696466..3697125 - 660 WP_059216760.1 hemolysin III family protein -
PS039_RS17895 (3697293) 3697293..3697604 - 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
PS039_RS17900 (3697649) 3697649..3699082 + 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271744 WP_000244763.1 NZ_CP117620:c3694546-3694142 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271744 WP_000354046.1 NZ_CP117620:c3694793-3694527 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References