Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 498845..499552 Replicon chromosome
Accession NZ_CP117620
Organism Escherichia albertii strain BIA_24

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag PS039_RS02440 Protein ID WP_161537416.1
Coordinates 499211..499552 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L1KVZ6
Locus tag PS039_RS02435 Protein ID WP_000939437.1
Coordinates 498845..499180 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS039_RS02410 (494524) 494524..495752 + 1229 WP_273809172.1 IS3-like element IS2 family transposase -
PS039_RS02415 (496336) 496336..496980 + 645 WP_273810144.1 hypothetical protein -
PS039_RS02420 (497040) 497040..497288 + 249 WP_233991479.1 hypothetical protein -
PS039_RS02425 (497524) 497524..498342 + 819 WP_161537418.1 DUF932 domain-containing protein -
PS039_RS02430 (498372) 498372..498845 + 474 WP_161537417.1 DNA repair protein RadC -
PS039_RS02435 (498845) 498845..499180 + 336 WP_000939437.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PS039_RS02440 (499211) 499211..499552 + 342 WP_161537416.1 TA system toxin CbtA family protein Toxin
PS039_RS02445 (499667) 499667..500500 + 834 WP_161537415.1 DUF4942 domain-containing protein -
PS039_RS02450 (500577) 500577..500825 + 249 WP_024187601.1 ribbon-helix-helix domain-containing protein -
PS039_RS02455 (500829) 500829..501104 + 276 WP_161537414.1 type II toxin-antitoxin system RelE/ParE family toxin -
PS039_RS02460 (501223) 501223..502014 + 792 WP_161537413.1 helix-turn-helix transcriptional regulator -
PS039_RS02465 (502286) 502286..503269 + 984 WP_161537412.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - vat 494847..513092 18245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13049.02 Da        Isoelectric Point: 9.5454

>T271724 WP_161537416.1 NZ_CP117620:499211-499552 [Escherichia albertii]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGQLRRCHNTTAR

Download         Length: 342 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12556.56 Da        Isoelectric Point: 7.6977

>AT271724 WP_000939437.1 NZ_CP117620:498845-499180 [Escherichia albertii]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3L1KVZ6

References