Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 59371..59996 Replicon plasmid pEA25_1
Accession NZ_CP117616
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name vapC Uniprot ID A0A828AN07
Locus tag PS046_RS23590 Protein ID WP_059257082.1
Coordinates 59371..59769 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8H9EG71
Locus tag PS046_RS23595 Protein ID WP_000450526.1
Coordinates 59769..59996 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS23570 (PS046_23570) 54481..56052 - 1572 WP_273811869.1 IS66 family transposase -
PS046_RS23575 (PS046_23575) 56072..56419 - 348 WP_273813306.1 IS66 family insertion sequence element accessory protein TnpB -
PS046_RS23580 (PS046_23580) 56419..57096 - 678 WP_001339397.1 IS66-like element accessory protein TnpA -
PS046_RS23585 (PS046_23585) 57173..59362 + 2190 WP_273813308.1 type IV conjugative transfer system coupling protein TraD -
PS046_RS23590 (PS046_23590) 59371..59769 - 399 WP_059257082.1 tRNA(fMet)-specific endonuclease VapC Toxin
PS046_RS23595 (PS046_23595) 59769..59996 - 228 WP_000450526.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 / espL2 / espL2 / espL2 / gspG / gspH / gspL / vat 1..100741 100741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14945.27 Da        Isoelectric Point: 7.8605

>T271721 WP_059257082.1 NZ_CP117616:c59769-59371 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNIREFERMDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.53 Da        Isoelectric Point: 4.5358

>AT271721 WP_000450526.1 NZ_CP117616:c59996-59769 [Escherichia albertii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828AN07

Antitoxin

Source ID Structure

References