Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 15045..15580 Replicon plasmid pEA25_1
Accession NZ_CP117616
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PS046_RS23335 Protein ID WP_059257247.1
Coordinates 15293..15580 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8H9KB11
Locus tag PS046_RS23330 Protein ID WP_001132891.1
Coordinates 15045..15296 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS23315 (PS046_23315) 10324..11301 - 978 WP_273813326.1 RepB family plasmid replication initiator protein -
PS046_RS23320 (PS046_23320) 12393..13559 + 1167 WP_059278927.1 plasmid-partitioning protein SopA -
PS046_RS23325 (PS046_23325) 13559..14530 + 972 WP_207610760.1 ParB/RepB/Spo0J family plasmid partition protein -
PS046_RS23330 (PS046_23330) 15045..15296 + 252 WP_001132891.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS046_RS23335 (PS046_23335) 15293..15580 + 288 WP_059257247.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS046_RS23340 (PS046_23340) 15717..16459 + 743 Protein_18 transposase -
PS046_RS23345 (PS046_23345) 16592..17323 + 732 Protein_19 IS66 family transposase -
PS046_RS23350 (PS046_23350) 17356..18003 - 648 Protein_20 transposase zinc-binding domain-containing protein -
PS046_RS23355 (PS046_23355) 18013..18201 - 189 Protein_21 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - espL2 / espL2 / espL2 / espL2 / gspG / gspH / gspL / vat 1..100741 100741
- flank IS/Tn - - 16574..17323 749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11194.26 Da        Isoelectric Point: 10.5832

>T271720 WP_059257247.1 NZ_CP117616:15293-15580 [Escherichia albertii]
MTYTVKFRDDALKEWMKLDKSIQQQFAKKLKKCSENPHIPSAKLRELKNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.39 Da        Isoelectric Point: 4.0780

>AT271720 WP_001132891.1 NZ_CP117616:15045-15296 [Escherichia albertii]
MPNIILSDTSASVSELKKNPMATVGAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References