Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3653446..3654064 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS046_RS17855 Protein ID WP_001280991.1
Coordinates 3653446..3653664 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS046_RS17860 Protein ID WP_000344798.1
Coordinates 3653690..3654064 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS17820 (3648735) 3648735..3649307 + 573 WP_000779847.1 YbaY family lipoprotein -
PS046_RS17825 (3649337) 3649337..3649648 - 312 WP_172843666.1 MGMT family protein -
PS046_RS17835 (3650029) 3650029..3650382 + 354 WP_000878151.1 DUF1428 family protein -
PS046_RS17840 (3650420) 3650420..3651970 - 1551 WP_001260378.1 EAL domain-containing protein -
PS046_RS17845 (3652134) 3652134..3652604 - 471 WP_000136188.1 YlaC family protein -
PS046_RS17850 (3652712) 3652712..3653269 - 558 WP_059221620.1 maltose O-acetyltransferase -
PS046_RS17855 (3653446) 3653446..3653664 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS046_RS17860 (3653690) 3653690..3654064 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS046_RS17865 (3654619) 3654619..3657768 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS046_RS17870 (3657791) 3657791..3658984 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271716 WP_001280991.1 NZ_CP117615:c3653664-3653446 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271716 WP_000344798.1 NZ_CP117615:c3654064-3653690 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References