Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2420700..2421304 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name doc Uniprot ID A0A8H9B4D1
Locus tag PS046_RS11880 Protein ID WP_059222236.1
Coordinates 2420918..2421304 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS046_RS11875 Protein ID WP_001195490.1
Coordinates 2420700..2420921 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS11860 (2416950) 2416950..2418401 + 1452 WP_095573909.1 tagaturonate reductase -
PS046_RS11865 (2418606) 2418606..2419520 + 915 WP_024164792.1 bestrophin family protein -
PS046_RS11870 (2419524) 2419524..2420282 - 759 WP_273811832.1 trans-aconitate 2-methyltransferase -
PS046_RS11875 (2420700) 2420700..2420921 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS046_RS11880 (2420918) 2420918..2421304 + 387 WP_059222236.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS046_RS11885 (2421487) 2421487..2425686 - 4200 WP_273811834.1 ESPR-type extended signal peptide-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14475.47 Da        Isoelectric Point: 8.0833

>T271710 WP_059222236.1 NZ_CP117615:2420918-2421304 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLADPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271710 WP_001195490.1 NZ_CP117615:2420700-2420921 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References