Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 950810..951461 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS046_RS04630 Protein ID WP_000244763.1
Coordinates 951057..951461 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS046_RS04625 Protein ID WP_000354046.1
Coordinates 950810..951076 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS04600 (946521) 946521..947954 - 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -
PS046_RS04605 (947999) 947999..948310 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS046_RS04610 (948478) 948478..949137 + 660 WP_000250281.1 hemolysin III family protein -
PS046_RS04615 (949578) 949578..950558 - 981 WP_059221136.1 tRNA-modifying protein YgfZ -
PS046_RS04620 (950590) 950590..950820 + 231 WP_000181267.1 hypothetical protein -
PS046_RS04625 (950810) 950810..951076 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS046_RS04630 (951057) 951057..951461 + 405 WP_000244763.1 protein YgfX Toxin
PS046_RS04635 (951500) 951500..952021 - 522 WP_059221135.1 flavodoxin FldB -
PS046_RS04640 (952133) 952133..953029 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS046_RS04645 (953054) 953054..953764 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS046_RS04650 (953770) 953770..955503 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271704 WP_000244763.1 NZ_CP117615:951057-951461 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271704 WP_000354046.1 NZ_CP117615:950810-951076 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References