Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 314381..315181 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag PS046_RS01465 Protein ID WP_095574314.1
Coordinates 314654..315181 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS046_RS01460 Protein ID WP_001277106.1
Coordinates 314381..314647 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS01440 (310038) 310038..310706 + 669 WP_000617720.1 cell division ATP-binding protein FtsE -
PS046_RS01445 (310699) 310699..311757 + 1059 WP_001042000.1 permease-like cell division protein FtsX -
PS046_RS01450 (312002) 312002..312856 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PS046_RS01455 (313128) 313128..314231 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS046_RS01460 (314381) 314381..314647 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS046_RS01465 (314654) 314654..315181 + 528 WP_095574314.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS046_RS01470 (315178) 315178..315561 - 384 WP_095574313.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS046_RS01475 (315985) 315985..317094 + 1110 WP_095574312.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS046_RS01480 (317142) 317142..318068 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS046_RS01485 (318065) 318065..319342 + 1278 WP_273812638.1 branched chain amino acid ABC transporter permease LivM -
PS046_RS01490 (319339) 319339..320106 + 768 WP_000082094.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19464.36 Da        Isoelectric Point: 6.6263

>T271702 WP_095574314.1 NZ_CP117615:314654-315181 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRACILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVCSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271702 WP_001277106.1 NZ_CP117615:314381-314647 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References