Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 150070..150682 Replicon chromosome
Accession NZ_CP117615
Organism Escherichia albertii strain BIA_25

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag PS046_RS00680 Protein ID WP_000833473.1
Coordinates 150070..150255 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PS046_RS00685 Protein ID WP_095574350.1
Coordinates 150272..150682 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS046_RS00665 (145534) 145534..146829 + 1296 WP_059268237.1 Fic family protein -
PS046_RS00670 (146937) 146937..148475 + 1539 WP_002460288.1 aldehyde dehydrogenase AldB -
PS046_RS00675 (148516) 148516..149595 - 1080 WP_172843676.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
PS046_RS00680 (150070) 150070..150255 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
PS046_RS00685 (150272) 150272..150682 + 411 WP_095574350.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PS046_RS00690 (150754) 150754..152718 - 1965 WP_095574349.1 glycoside hydrolase family 127 protein -
PS046_RS00695 (152729) 152729..154129 - 1401 WP_095574348.1 MFS transporter -
PS046_RS00700 (154355) 154355..155170 + 816 WP_095574347.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T271699 WP_000833473.1 NZ_CP117615:150070-150255 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15231.11 Da        Isoelectric Point: 4.5486

>AT271699 WP_095574350.1 NZ_CP117615:150272-150682 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVSGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure

References