Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 4281024..4282068 | Replicon | chromosome |
| Accession | NZ_CP117609 | ||
| Organism | Escherichia albertii strain BIA_26 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | PS038_RS20530 | Protein ID | WP_053878051.1 |
| Coordinates | 4281024..4281572 (-) | Length | 183 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A799QL68 |
| Locus tag | PS038_RS20535 | Protein ID | WP_059242328.1 |
| Coordinates | 4281595..4282068 (-) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PS038_RS20505 (4277551) | 4277551..4278333 | - | 783 | WP_001317493.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| PS038_RS20510 (4278330) | 4278330..4279352 | - | 1023 | WP_000255944.1 | IS21-like element IS100 family transposase | - |
| PS038_RS20515 (4279543) | 4279543..4280109 | + | 567 | WP_273818214.1 | DUF551 domain-containing protein | - |
| PS038_RS20520 (4280109) | 4280109..4280681 | + | 573 | WP_273818294.1 | 3'-5' exonuclease | - |
| PS038_RS20525 (4280718) | 4280718..4280990 | + | 273 | WP_024237202.1 | pyocin activator PrtN family protein | - |
| PS038_RS20530 (4281024) | 4281024..4281572 | - | 549 | WP_053878051.1 | hypothetical protein | Toxin |
| PS038_RS20535 (4281595) | 4281595..4282068 | - | 474 | WP_059242328.1 | DUF4065 domain-containing protein | Antitoxin |
| PS038_RS20540 (4282591) | 4282591..4283106 | + | 516 | WP_002460756.1 | zinc uptake transcriptional repressor Zur | - |
| PS038_RS20545 (4283147) | 4283147..4283356 | - | 210 | WP_001030604.1 | CsbD family protein | - |
| PS038_RS20550 (4283472) | 4283472..4284797 | - | 1326 | WP_059218964.1 | MATE family efflux transporter DinF | - |
| PS038_RS20555 (4284872) | 4284872..4285480 | - | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
| PS038_RS20560 (4285590) | 4285590..4285958 | - | 369 | WP_000002912.1 | diacylglycerol kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4227316..4289584 | 62268 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 183 a.a. Molecular weight: 20096.62 Da Isoelectric Point: 4.5890
>T271694 WP_053878051.1 NZ_CP117609:c4281572-4281024 [Escherichia albertii]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFEPSNHESDDDSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFEPSNHESDDDSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK
Download Length: 549 bp
Antitoxin
Download Length: 158 a.a. Molecular weight: 17369.87 Da Isoelectric Point: 7.9143
>AT271694 WP_059242328.1 NZ_CP117609:c4282068-4281595 [Escherichia albertii]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQTYNGIGSSIIPDDAIKTYYHDLLNNRQQCQGL
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQTYNGIGSSIIPDDAIKTYYHDLLNNRQQCQGL
Download Length: 474 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|