Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 3945771..3946478 Replicon chromosome
Accession NZ_CP117609
Organism Escherichia albertii strain BIA_26

Toxin (Protein)


Gene name ykfI Uniprot ID A0A4T3Q6D2
Locus tag PS038_RS18845 Protein ID WP_001683515.1
Coordinates 3945771..3946112 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag PS038_RS18850 Protein ID WP_059219072.1
Coordinates 3946143..3946478 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS038_RS18825 (3943304) 3943304..3944101 - 798 WP_059219074.1 helix-turn-helix transcriptional regulator -
PS038_RS18830 (3944219) 3944219..3944494 - 276 WP_000409332.1 type II toxin-antitoxin system RelE/ParE family toxin -
PS038_RS18835 (3944498) 3944498..3944746 - 249 WP_000535212.1 ribbon-helix-helix domain-containing protein -
PS038_RS18840 (3944823) 3944823..3945656 - 834 WP_059219073.1 DUF4942 domain-containing protein -
PS038_RS18845 (3945771) 3945771..3946112 - 342 WP_001683515.1 TA system toxin CbtA family protein Toxin
PS038_RS18850 (3946143) 3946143..3946478 - 336 WP_059219072.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PS038_RS18855 (3946478) 3946478..3946951 - 474 WP_059219071.1 DNA repair protein RadC -
PS038_RS18860 (3946981) 3946981..3947799 - 819 WP_059219070.1 DUF932 domain-containing protein -
PS038_RS18865 (3948035) 3948035..3948988 - 954 WP_059219069.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13034.05 Da        Isoelectric Point: 9.5454

>T271693 WP_001683515.1 NZ_CP117609:c3946112-3945771 [Escherichia albertii]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCHNTTAR

Download         Length: 342 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12588.56 Da        Isoelectric Point: 7.1865

>AT271693 WP_059219072.1 NZ_CP117609:c3946478-3946143 [Escherichia albertii]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADDELSACQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4T3Q6D2

Antitoxin

Source ID Structure

References