Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3309198..3309816 Replicon chromosome
Accession NZ_CP117609
Organism Escherichia albertii strain BIA_26

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS038_RS15855 Protein ID WP_001280991.1
Coordinates 3309598..3309816 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS038_RS15850 Protein ID WP_000344798.1
Coordinates 3309198..3309572 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS038_RS15840 (3304278) 3304278..3305471 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS038_RS15845 (3305494) 3305494..3308643 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS038_RS15850 (3309198) 3309198..3309572 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS038_RS15855 (3309598) 3309598..3309816 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS038_RS15860 (3309993) 3309993..3310550 + 558 WP_000093562.1 maltose O-acetyltransferase -
PS038_RS15865 (3310658) 3310658..3311128 + 471 WP_059218730.1 YlaC family protein -
PS038_RS15870 (3311292) 3311292..3312842 + 1551 WP_059218786.1 EAL domain-containing protein -
PS038_RS15875 (3312880) 3312880..3313233 - 354 WP_000878151.1 DUF1428 family protein -
PS038_RS15885 (3313614) 3313614..3313925 + 312 WP_000409915.1 MGMT family protein -
PS038_RS15890 (3313955) 3313955..3314527 - 573 WP_059216668.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271685 WP_001280991.1 NZ_CP117609:3309598-3309816 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271685 WP_000344798.1 NZ_CP117609:3309198-3309572 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References